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KMID : 1001920090450030151
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Journal of Korean Neurosurgical Society
2009 Volume.45 No. 3 p.151 ~ p.156
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Does Serum Osmolarity Change as a Result of the Reflex Neuroprotective Mechanism of Cerebral Osmo-Regulation after Minor Head Trauma?
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Naci Balak
Nilgun Isiksacan
Recai Turkoglu
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Abstract
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Objective : It is well known that changes in cerebral hemodynamics occur after traumatic brain injury (TBI). Osmo-regulation in the brain is important for maintaining a constant milieu in the central nervous system. Nevertheless, to our knowledge, early osmolarity changes after minor head injury have not been studied until now.
Methods : In this study, serum osmolarity was measured in 99 patients with minor head trauma. As a control group, blood samples were drawn from 99 patients who had a minor trauma in an extremity. Serum osmolarity was estimated using a fully automatic biochemical autoanalyzer within the first 3 hours after the trauma.
Results : The mean serum osmolarity levels were 286.08±10.17 mOsm/L in the study group and 290.94±5.65 mOsm/L in the control group (p<0.001). However, after age adjustment between the study and control groups, this statistical significance was found to be valid only for patients over 30 years of age.
Conclusion : It was noted that serum osmolarity levels decrease in the first 3 hours following minor head trauma in patients over 30 years of age. Further studies into this area could provide guidance for the management/treatment of elderly patients
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KEYWORD
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Biomarkers, Brain injury, Head trauma, Neurophysiology, Osmolarity
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